Conventional Antifungal Therapies Antifungal Peptides

Natural antifungal peptides are derived from bacteria (iturin, bacillomycin, syringi-otoxins, cepacidines), fungi (echinocandins), insects (cecropins A and B, drosomycin, dermaseptin), plants (zeamatin, the cyclopeptide alkaloids amphibine H, franguflo-line, nummularine), and mammals (a- and P-defensins, HNP series, gallinacin) (De Lucca and Walsh, 2000). Antifungal peptides are either linear sequences or folded structures with hydrophobic or amphipathic properties. The recombinant defensin Tfgd1 synthesized from a cDNA cloned from Trigonella foenum-graecum exhibits broad spectrum antifungal activity (Olli and Kirti, 2006). The synthetic peptide D4E1 is active against Aspergillus with a 50% lethal dose of 2.1-16.8 |g/mL (De Lucca and Walsh, 2000). MICs of the synthetic peptide halocidin analog di-K19Hc against clinical isolates of C. albicans and Aspergillus sp. are below 4 and 16 8 |g/ mL, respectively (Jang et al., 2006). It rapidly (<30 s) kills C. albicans by binding to cell wall P-(1,3)-glucan and forming membrane ion channels. The synthetic lactoferrin-derived peptide (Lfpep) and the kaliocin-1 peptide, which includes the sequences 18-40 and 153-183 of the human lactoferin protein, respectively, are fungicidal against fluconazole- and AMB-resistant C. albicans strains (Viejo-Diaz et al., 2005). Lfpep kills C. albicans by permealizing the plasma membrane evidenced by the ability of propidium iodide to permeate Lfpep-treated cells (Viejo-Diaz et al., 2005). Generally speaking, antifungal peptides kill or inhibit the growth of fungi by lysis, binding, and disruption of plasma membranes, pore formation and leakage, or by interacting with cytoplasmic or nuclear targets (De Lucca and Walsh, 2000).

Cure Your Yeast Infection For Good

Cure Your Yeast Infection For Good

The term vaginitis is one that is applied to any inflammation or infection of the vagina, and there are many different conditions that are categorized together under this ‘broad’ heading, including bacterial vaginosis, trichomoniasis and non-infectious vaginitis.

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