Although several non-dematiaceous molds can cause opportunistic fungal infections to humans, only Fusarium and Scedosporium spp. have been recognized as emerging pathogens with significant morbidity and mortality especially in immunocompromised patients. Our understanding of Fusarium and Scedosporium spp. has been advanced during the last decade. Currently, new molecular methods can be used additionally to conventional techniques to provide an earlier and better documented diagnosis even to the species level. In addition, new findings on the host immune response, based on PMN and MNC function, have been studied and well documented.

The current knowledge on the management of fusariosis and scedosporiosis primarily depends on in vitro and in vivo studies due to the low incidence of these mycoses and the subsequent difficulty in performing large clinical trials with sufficient predictive power. However, early aggressive treatment with high doses of standard antifungal drugs, combination treatment and newer antifungals agents, especially new azoles, seem to be very promising for the management of these difficult to treat infections. In addition, hemopoietic growth factors plus granulocyte transfusions can be potential adjuvant therapeutic strategies.

Future studies should aim to determine whether combination therapy with new agents, hemopoietic growth factors and cytokines, improves survival and treatment outcome in the most seriously debilitated patients who are afflicted with life-threatening infections due to Fusarium and Scedosporium spp.

Cure Your Yeast Infection For Good

Cure Your Yeast Infection For Good

The term vaginitis is one that is applied to any inflammation or infection of the vagina, and there are many different conditions that are categorized together under this ‘broad’ heading, including bacterial vaginosis, trichomoniasis and non-infectious vaginitis.

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