Calcineurin Signaling

Calcineurin is a conserved calcium-calmodulin-regulated protein phosphatase that consists of a catalytic A subunit and a regulatory B subunit. Both subunits are required for protein function, growth at high temperatures, and virulence in mice (Odom et al., 1997; Fox et al., 2001). The phosphatase function of calcineurin is inhibited by the immunosuppressive drugs cyclosporine A and FK506, which bind cyclophilin A and FKBP12, respectively (Kraus & Heitman, 2003). Cn contains two homologous genes for cyclophilin A, both of which are required for cell growth, mating, virulence in mice, and toxicity to cyclosporine A (Wang et al., 2001). Due to these toxic effects of cyclosporine A, research is ongoing to find analogs that are nonimmunosuppressive as potential antifungals against Cn (Cruz et al., 2000). Calcineurin affects Cn virulence in a variety of ways as it is also involved in cell wall integrity (mutants lacking the MAP kinase mpk1 are defective in growth at high temperatures (Kraus et al., 2003), hyphal elongation during mating (Fox & Heitman, 2005), and haploid fruiting (Cruz et al., 2001).

Cure Your Yeast Infection For Good

Cure Your Yeast Infection For Good

The term vaginitis is one that is applied to any inflammation or infection of the vagina, and there are many different conditions that are categorized together under this ‘broad’ heading, including bacterial vaginosis, trichomoniasis and non-infectious vaginitis.

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