Antifungal Therapies Targeting the Host

The degree to which a specific immune component participates in responding to fungal pathogens varies depending on the species of the pathogen, its morphotype (yeast, pseudohyphae or hyphae), the anatomical site, and form of the infection (Shoham & Levitz, 2005; Matthews & Burnie, 2004) (Figure 4.1). Phagocytic cells present within the target organ and those recruited by chemotactic mediators participate in reducing fungal burden by killing significant percentages of fungal cells. Intracellular and extracellular killing of fungi is mediated by reactive oxygen species and antimicrobial peptides. The importance of neutrophils is evidenced by increased susceptibility of neutropenic patients and experimental animals to candi-diasis. Along with their capacity to express T cell co-stimulatory molecules, dendritic cells (DCs) capture and process fungal antigens making them potent fungal antigen presenting cells. Hence, DCs can initiate a cascade of innate and acquired

K. Kavanagh (ed.), New Insights in Medical Mycology. © Springer 2007

Antifungal Therapies

Antifungal Therapies

Novel

- Monoclonal Antibodies

- Oligonucleotides

- Antineoplastic agents

Targeting Host

Targeting Pathogen (Fungi)

Targeting Host

Figure 4.1 General summary of antifungal therapies

Novel

- Monoclonal Antibodies

- Oligonucleotides

- Antineoplastic agents

Targeting Pathogen (Fungi)

Figure 4.1 General summary of antifungal therapies immune responses against fungi. Defects in cell-mediated immunity (CMI) are strongly associated with chronic mucocutaneous candidiasis. Differentiation of Th cells into either Th1 or Th2 type often determines susceptibility or resistance to several fungal infections. Differentiation of Th cells into Th1 is a prerequisite for protection against vaginal candidiasis. The production of protective monoclonal antibodies against Candida albicans and Cryptococcus neoformans infections is well established. Additionally, systemic candidiasis often results in the production of protective polyclonal antisera.

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Cure Your Yeast Infection For Good

Cure Your Yeast Infection For Good

The term vaginitis is one that is applied to any inflammation or infection of the vagina, and there are many different conditions that are categorized together under this ‘broad’ heading, including bacterial vaginosis, trichomoniasis and non-infectious vaginitis.

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