Antibody Therapy

A monoclonal antibody to GXM, 18B7, underwent preliminary testing for treatment of cryptococcosis (Casadevall et al., 1998). In phase I clinical trials with HIV-infected patients, 18B7 administration correlates with reduced antigen titers in serum. This study is the first to use mAbs as therapy against a fungal infection (Larsen et al., 2005). Another groundbreaking therapy, the use of radioiummuno-therapy against microbial infection, utilizes 18B7. In such a therapy, antibody is radiolabeled with the P-emitter Rhenium-188 and administered to Cn-infected mice. The radiolabeled antibodies kill Cn in vitro, and more importantly, increase the survival time of the mice and reduce fungal burden in the lung and brain (Dadachova et al., 2003).

Cure Your Yeast Infection For Good

Cure Your Yeast Infection For Good

The term vaginitis is one that is applied to any inflammation or infection of the vagina, and there are many different conditions that are categorized together under this ‘broad’ heading, including bacterial vaginosis, trichomoniasis and non-infectious vaginitis.

Get My Free Ebook


Post a comment