The Potential Application of Antioxidant Agents in Alzheimer Disease Therapeutics

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Paula I. Moreira, Mark A. Smith, Xiongwei Zhu, Akihiko Nunomura, and George Perry

Abstract: Oxidative stress is a fundamental process contributing to the neuronal degeneration and death observed in Alzheimer disease, and many studies using markers of oxidative damage have provided evidence supporting this hypothesis. Consequently, antioxidants that prevent the detrimental consequences of oxidative stress are considered to be a promising approach to neuroprotection. While the clinical value of antioxidants for the prevention of AD is currently ambiguous, they still appear to be the most promising weapons that can be developed against disease progression.

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