Vaccine vectors

An alternative approach to the development of novel vaccine products entails the use of live vaccine vectors. The strategy followed involves incorporation of a gene/cDNA coding for a pathogen-derived antigen into a non-pathogenic species. If the resultant recombinant vector expresses the gene product on its surface, then it may be used to immunize against the pathogen of interest (Figure 13.12).

Most vaccine vectors developed to date are viral based, with poxviruses (as well as picorna viruses and adenoviruses) being used most. In general, such recombinant viral vectors elicit both

(a)

Figure 13.11 Photographs illustrating some deanroom-based processing equipment utilized in the manufacture of SmithKline Beecham's hepatitis B surface antigen product. (a) A chromatographic fractionation system, consisting of (from left to right) fraction collector, control tower and chromatographic columns (stacked formation). (b) Some of the equipment used to formulate the vaccine finished product. Photograph courtesy of SmithKline Beecham Biologicals s.a., Belgium

Figure 13.11 Photographs illustrating some deanroom-based processing equipment utilized in the manufacture of SmithKline Beecham's hepatitis B surface antigen product. (a) A chromatographic fractionation system, consisting of (from left to right) fraction collector, control tower and chromatographic columns (stacked formation). (b) Some of the equipment used to formulate the vaccine finished product. Photograph courtesy of SmithKline Beecham Biologicals s.a., Belgium

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