The interleukins as haemopoietic growth factors

The interleukin family of cytokines has been overviewed in Chapter 9, and a number of cytokines are known to influence haemopoiesis. The IL-3 receptor, for example, is found on a wide variety of progenitor haemopoietic cells, and appears to stimulate not only CFU-GEMM, but also the precursor cells of basophils, eosinophils and platelets. The role of IL-11, which also plays a role, was also discussed in Chapter 9.

HAEMATOPOIETIC GROWTH FACTORS Table 10.5 Summary of some of the properties of G-CSF, M-CSF and GM-CSF

G-CSF

M-CSF

GM-CSF

Molecular mass (kDa) 21

Main producer cells Bone marrow stromal

45-90

Lymphocytes

Macrophages T-lymphocytes Fibroblasts Endothelial cells

cell Macrophages Fibroblasts

Myoblasts Osteoblasts Monocytes Fibroblasts

Main target cells

Neutrophils. Also other haemopoietic

Endothelial cells Macrophages and their precursor cells

Haematopoietic progenitor cells Granulocytes Monocytes Endothelial cells Megakaryocytes T-lymphocytes Erythroid cells progenitors and endothelial cells

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