The gonadotropins

The gonadotrophins are a family of hormones for which the gonads represent their primary target (Table 11.8). They directly and indirectly regulate reproductive function and, in some cases, the development of secondary sexual characteristics. Insufficient endogenous production of any

Table 11.7 rhGH preparations approved for general medical use

Product (tradename)

Company

Indication

Humatrope

Eli Lilly

hGH deficiency in children

Nutropin

Genentech

hGH deficiency in children

Nutropin AQ

Schwartz Pharma AG

Growth failure, Turner's syndrome

BioTropin

Biotechnology General

hGH deficiency in children

Genotropin

Pharmacia & Upjohn

hGH deficiency in children

Saizen

Serono Laboratories

hGH deficiency in children

Serostim

Serono Laboratories

Treatment of AIDS-associated

catabolism/wasting

Norditropin

Novo Nordisk

Treatment of growth failure in

children due to inadequate

growth hormone secretion

Omnitrop

Sandoz

Treatment of children and adults

with certain forms of growth

disturbance

Valtropin

Biopartners

Treatment of children and adults

with certain forms of growth

disturbance

Somavert (hGH analogue, i.e.

Pharmacia

Treatment of selected patients

antagonist)

suffering from acromegaly

Figure 11.9 Production of rhGH in E. coli (as an intracellular protein). Subsequent to fermentation, the cells are collected by centrifugation or filtration. After homogenization, nucleic acids and some membrane constituents are precipitated by the addition of polyethyleneimine. Ammonium sulfate precipitation of the supernatant concentrates the crude rhGH preparation. Chromatographic purification follows, as illustrated

Figure 11.9 Production of rhGH in E. coli (as an intracellular protein). Subsequent to fermentation, the cells are collected by centrifugation or filtration. After homogenization, nucleic acids and some membrane constituents are precipitated by the addition of polyethyleneimine. Ammonium sulfate precipitation of the supernatant concentrates the crude rhGH preparation. Chromatographic purification follows, as illustrated member of this family will adversely affect reproductive function, which generally can be treated by administration of an exogenous preparation of the hormone in question. Most gonadotrophins are synthesized by the pituitary, although some are made by reproductive and associated tissues.

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