The biological activities of interleukin1

IL-1 mediates a wide variety of biological activities:

• It is a pro-inflammatory cytokine, promoting the synthesis of various substances such as eicosanoids, as well as proteases and other enzymes involved in generating inflammatory mediators. This appears to be its major biological function.

• It plays a role in activating B-lymphocytes, along with additional cytokines, and may also play a role in activating T-lymphocytes.

• Along with IL-6, it induces synthesis of acute-phase proteins in hepatocytes.

• It acts as a co-stimulator of haematopoietic cell growth/differentiation.

The relative prominence of these various biological activities depends largely upon the quantities of IL-1 produced in any given situation. At low concentrations, its effects are largely paracrine, e.g. induction of local inflammation. At elevated concentrations, it acts more in an endocrine manner, inducing systematic effects, such as the hepatic synthesis of acute-phase proteins, but also induction of fever (hence the name, endogenous pyrogen) and cachexia (general body wasting, such as that associated with some cancers). Many of these biological activities are also promoted by TNF, which is another example of cytokine redundancy.

In addition to IL-1a and -1p, a third IL-1-like protein has been identified, termed IL-1 receptor antagonist (IL-1Ra). As its name suggests, this molecule appears to be capable of binding to the IL-1 receptors without triggering an intracellular response.

10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

Get My Free Ebook


Post a comment