Macrophage colonystimulating factor

M-CSF serves as a growth, differentiation and activation factor for macrophages and their precursor cells. It is also known as CSF-1. This cytokine is produced by various cell types (Table 10.5). The mature form is a glycoprotein containing three potential N-linked glycosylation sites. Three related forms of human M-CSF have been characterized. All are ultimately derived from the same gene and share common C and N termini. The largest consists of 522 amino acids, with the 406 and 224 amino acid forms lacking different lengths of the internal sequence of the 522 form. The molecular masses of these mature M-CSFs range from 45 to 90 kDa.

The biologically active form of M-CSF is a homodimer (two identical subunits). These homodimers can exist as integral cell surface proteins, or may be released from their producer cell by proteolytic cleavage, thus yielding the soluble cytokine. The M-CSF receptor is a single-chain, heavily glycosylated, polypeptide of molecular mass 150 kDa.

Supplements For Diabetics

Supplements For Diabetics

All you need is a proper diet of fresh fruits and vegetables and get plenty of exercise and you'll be fine. Ever heard those words from your doctor? If that's all heshe recommends then you're missing out an important ingredient for health that he's not telling you. Fact is that you can adhere to the strictest diet, watch everything you eat and get the exercise of amarathon runner and still come down with diabetic complications. Diet, exercise and standard drug treatments simply aren't enough to help keep your diabetes under control.

Get My Free Ebook

Post a comment