Antibody fragments

One limitation to antibody-mediated treatment of solid tumours relates to their poor penetration of tumour mass. Antibody-based tumour therapy (e.g. using radiolabelled murine monoclonals) has proved more effective in treating disseminated cancers (e.g. leukaemias and lymphomas) as opposed to solid tumours. The physical size of the intact antibody likely hinders tumour penetration. As a result, recent interest has focused upon using antibody fragments that retain their antigen-binding capabilities. Fragments, such as F(ab), F(ab)2 and Fv (Box 13.2), can be easily generated, mainly via recombinant DNA technology. These have been labelled with, for example, radioactive tags with the intention of using them as diagnostic and therapeutic agents. Although their lower molecular mass may aid more effective tumour penetration, whole chimaeric/humanized antibodies may be more effective, particularly if used for therapeutic purposes. Fragments generally display greatly reduced serum half-lives (Table 13.4) and cannot initiate effector functions. Radiolabelled fragments may be better suited to diagnostic imaging purposes.

Supplements For Diabetics

Supplements For Diabetics

All you need is a proper diet of fresh fruits and vegetables and get plenty of exercise and you'll be fine. Ever heard those words from your doctor? If that's all heshe recommends then you're missing out an important ingredient for health that he's not telling you. Fact is that you can adhere to the strictest diet, watch everything you eat and get the exercise of amarathon runner and still come down with diabetic complications. Diet, exercise and standard drug treatments simply aren't enough to help keep your diabetes under control.

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