(1) Uses. Nefazodone hydrochloride is an oral antidepressant that is totally unrelated to the other available antidepressants.
(2) Adverse effects. The adverse effects of nefazodone hydrochloride are similar to selective serotonin reuptake inhibitors.
(a) The drug is contraindicated in patients who are taking other monoamine oxidase (MAO) inhibitors, and those having hypersensitivity to nefazodone or other phenylpiperazine antidepressants.
(b) The drug is contraindicated on patients who are taking nonsedating antihistimines (that is, Terfenadine and Astemizole).
(4) Cautions and warnings. Patients taking nefazodone hydrocloride should be cautioned against the following:
(a) The drug may produce drowsiness.
(b) The patient should not consume any alcohol while taking the drug.
(c) Patients with cardiovascular or cerebrovascular disease that could be exacerbated by hypotension should use with caution.
(d) The potential for a fatal outcome is significantly increased by the concurrent use of alprazolam and triazolam.
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