B Imipramine Hydrochloride Tofranil

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(1) Uses. Imipramine is used to treat depression; however, it can paradoxically aggravate the anxiety sometimes associated with depression. Imipramine also produces an anticholinergic effect and is therefore approved by the Food and Drug Administration (FDA) for the treatment of enuresis (bedwetting) in children.

effects:

anxiety).

(2) Adverse effects. Imipramine may produce the following adverse

(a) Cardiovascular effects (that is, orthostatic hypotension).

(b) Central nervous system effects (for example, confusion and

(c) Gastrointestinal effects (that is, nausea and vomiting).

(d) Anticholinergic effects (for example, dry mouth and constipation).

(3) Cautions and warnings.

(a) Abruptly taking the drug away from the patient after long-term therapy may produce withdrawal symptoms.

(b) The drug may produce drowsiness.

(c) The patient should not consume any alcohol while taking the drug.

(d) The drug should be used with caution in patients with glaucoma or urinary retention because of its anticholinergic effects.

(1) Uses. Desipramine is used to treat depression. It has also been used in facilitating withdrawal from cocaine.

(2) Adverse effects. Desipramine is closely related to imipramine but has only minimal cardiovascular, CNS, GI, and anticholinergic effects.

(3) Cautions and warnings.

(a) Abruptly taking the drug away from the patient after long-term therapy may produce withdrawal symptoms.

(b) The drug may produce drowsiness.

(c) The patient should not consume any alcohol while taking the drug.

(d) The drug should be used with caution in patients with glaucoma or urinary retention because of its anticholinergic effects.

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Anxiety and Depression 101

Anxiety and Depression 101

Everything you ever wanted to know about. We have been discussing depression and anxiety and how different information that is out on the market only seems to target one particular cure for these two common conditions that seem to walk hand in hand.

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