AChlorpromazine Thorazine

(1) Uses. Chlorpromazine is a phenothiazine drug (a particular class of drugs) used in the treatment of acute and chronic psychoses. It is also used as a pre-or postoperative agent in the prevention of nausea and vomiting.

(2) Adverse effects. Chlorpromazine produces three major adverse effects:

(a) Extrapyramidal reactions. These reactions are frequently seen in both young and elderly patients who are taking large doses of the drug.

(b) Drowsiness.

(c) Orthostatic hypotension. Orthostatic hypotension is most likely to occur when the patient has been administered the drug intravenously. This can be prevented by having the patient remain reclined for at least one hour after the administration of the drug.

(d) Dryness of the mouth.

(3) Cautions and warnings. Chlorpromazine should not be prescribed to patients who have liver disease or glaucoma. Furthermore, patients taking the drug should be cautioned not to drink alcoholic beverages.

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