Routes of ATP generation in skeletal muscle

The major pathways for generation of ATP in muscle are illustrated in Fig. 4.12. Skeletal muscle uses both stored fuel (glycogen and triacylglycerol) and substrates (glucose and fatty acids) taken up from the blood. The fatty acids may be either plasma non-esterified fatty acids, or esterified fatty acids carried in the form of triacylglycerol in lipoproteins.


Triacylglycerol (in lipoprotein particles)

Fig. 4.12 Energy (ATP) generation in skeletal muscle. Only major pathways are shown: each arrow may represent one or more steps in a pathway. The major sites of regulation are shown: a plus sign indicates stimulation. FAT(P) represents a possible fatty acid transporter but it is not clear which might be most important in skeletal muscle (see Table 2.4). It is also possible that fatty acids released by lipoprotein lipase (LPL) (situated in the capillaries) might be transported into the cell by this means. TAG, triacylglycerol; TCA cycle, tricarboxylic acid (Krebs) cycle. The way in which muscle contraction is coordinated with metabolism is discussed in Section 8.4.3.

Lactate cycle ,_t

Triacylglycerol (in lipoprotein particles)

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