■50th centile 2nd centile

0123456789 10 Age (years)

Fig. 11.2 Growth of a child with leptin deficiency due to a mutation in the leptin gene. The lower lines show normal growth curves. The data for the child are marked with diamonds. The point at which treatment with recombinant leptin was started is shown by the arrow. From Farooqi, I.S., Jebb, S.A. & Langmack, G. et al. (1999) Effects of recombinant leptin therapy in a child with congenital leptin deficiency. N Engl J Med 341: 879-884. With permission. Copyright © 1996 Massachusetts Medical Society. All rights reserved.

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