Further reading

Membrane transporters

Palacin, M., Estévez, R., Bertran, J. & Zorzano, A. (1998) Molecular biology of mammalian plasma membrane amino acid transporters. Physiol Rev 78:969-1054.

Shepherd, P.R. & Kahn, B.B. (1999) Glucose transporters and insulin action. Implications for insulin resistance and diabetes mellitus. N Engl J Med 341: 248-257.

Abumrad, N., Coburn, C. & Ibrahimi, A. (1999) Membrane proteins implicated in long-chain fatty acid uptake by mammalian cells: CD36, FATP and FABPm. Biochim Biophys Acta 1441: 4-13.

Zorzano, A., Fandos, C. & Palacin, M. (2000) Role of plasma membrane transporters in muscle metabolism. Biochem J 349: 667-688.

Watson, R.T. & Pessin, J.E. (2001) Intracellular organization of insulin signaling and GLUT4 translocation. Recent Prog Horm Res 56: 175-193.

Schmitz, G., Langmann, T. & Heimerl, S. (2001) Role of ABCG1 and other ABCG family members in lipid metabolism. J Lipid Res 42: 1513-1520.

(See also Further Reading in Chapter 9 for additional reviews on ABC family transporters)

Signal transduction

Cohen, P. (1999) The Croonian Lecture 1998. Identification of a protein kinase cascade of major importance in insulin signal transduction. Philos Trans R Soc Lond B Biol Sci 354: 485-495.

Newgard, C.B., Brady, M.J., O'Doherty, R.M. & Saltiel, A.R. (2000) Organizing glucose disposal: emerging roles of the glycogen targeting subunits of protein phosphatase-1. Diabetes 49: 1967-1977.

Vanhaesebroeck, B. & Alessi, D.R. (2000) The PI3K-PDK1 connection: more than just a road to PKB. Biochem J 346: 561-576.

Downward, J. (2001) The ins and outs of signalling. Nature 411: 759-762

Frame, S. & Cohen, P. (2001) GSK3 takes centre stage more than 20 years after its discovery. Biochem J 359: 1-16.

Vanhaesebroeck, B., Leevers, S.J., Ahmadi, K. et al. (2001) Synthesis and function of 3-phosphorylated inositol lipids. Annu Rev Biochem 70: 535-602.

Winder, WW. (2001) Energy-sensing and signaling by AMP-activated protein kinase in skeletal muscle. J Appl Physiol 91: 1017-1028.

Bickel, P.E. (2002) Lipid rafts and insulin signaling. Am J Physiol Endocrinol Metab 282: E1-E10.


Kersten, S., Desverg Kersten, S., Desvergne, B. & Wahli, W. (2000) Roles of PPARs in health and disease. Nature 405: 421-424.

Osborne, T.F. (2000) Sterol regulatory element-binding proteins (SREBPs): key regulators of nutritional homeostasis and insulin action. J Biol Chem 275: 32379-32382.

Shimano, H. (2001) Sterol regulatory element-binding proteins (SREBPs): transcriptional regulators of lipid synthetic genes. Prog Lipid Res 40: 439-452.

Torra, I.P., Chinetti, G., Duval, C., Fruchart, J.C. & Staels, B. (2001) Peroxisome proliferator-activated receptors: from transcriptional control to clinical practice. Curr Opin Lipidol 12: 245-254.

Horton, J.D., Goldstein, J.L. & Brown, M.S. (2002) SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J Clin Invest 109: 1125-1131.

Walczak, R. & Tontonoz, P. (2002) PPARadigms and PPARadoxes: expanding roles for PPARy in the control of lipid metabolism. J Lipid Res 43: 177186.

Nutrient and hormone control of gene expression

O'Brien, R.M. & Granner, D.K. (1996) Regulation of gene expression by insulin. Physiol Rev 76: 1109-1161.

Duplus, E., Glorian, M. & Forest, C. (2000) Fatty acid regulation of gene transcription. J Biol Chem 275: 3 0749-3 0752.

Rutter, G.A., Tavare, J.M. & Palmer, D.G. (2000) Regulation of mammalian gene expression by glucose. News Physiol Sci 15: 149-154.

Sanderson, I.R. & Naik, S. (2000) Dietary regulation of intestinal gene expression. Annu Rev Nutr 20: 311-338.

Bruhat, A. & Fafournoux, P. (2001) Recent advances on molecular mechanisms involved in amino acid control of gene expression. Curr Opin Clin Nutr Metab Care 4: 439-443.

Christie, G.R., Hyde, R. & Hundal, H.S. (2001) Regulation of amino acid transporters by amino acid availability. Curr Opin Clin Nutr Metab Care 4: 425-431.

Ferraris, R.P. (2001) Dietary and developmental regulation of intestinal sugar transport. Biochem J 360: 265-276.

Semenza, G.L. (2001) Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology. Trends Mol Med 7: 345-350.

Towle, H.C. (2001) Glucose and cAMP: adversaries in the regulation of hepatic gene expression. Proc Natl Acad Sci USA 98: 13476-13478.

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