Further reading

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Articles marked * all come from a Nature Insight section on Diabetes in which there are also other good reviews: Nature 2001; 414: 781-827.

General diabetes, insulin resistance

Reaven, G.M. (1988) Role of insulin resistance in human disease. Diabetes 37: 1595-1607. This is a 'classic' article in which Gerald Reaven set out the now well-accepted idea that insulin resistance was an underlying feature of several conditions associated with increased risk of developing Type 2 diabetes and coronary heart disease. *Zimmet, P., Alberti, K.G. & Shaw, J. (2001) Global and societal implications of the diabetes epidemic. Nature 414: 782-787.

Genetics of diabetes

McCarthy, M. & Menzel, S. (2001) The genetics of type 2 diabetes. Br J Clin

Pharmacol 51: 195-199. Redondo, M.J. & Eisenbarth, G.S. (2002) Genetic control of autoimmunity in Type 1 diabetes and associated disorders. Diabetologia 45: 605-622.

Metabolism and insulin secretion in diabetes mellitus and its treatment

*Bell, G.I. & Polonsky, K.S. (2001) Diabetes mellitus and genetically programmed defects in P-cell function. Nature 414: 788-791. Langin, D. (2001) Diabetes, insulin secretion, and the pancreatic beta-cell mitochondrion. N Engl J Med 345: 1772-1774. *Moller, D.E. (2001) New drug targets for type 2 diabetes and the metabolic syndrome. Nature 414: 821-827. *Saltiel, A.R. & Kahn, C.R. (2001) Insulin signalling and the regulation of glucose and lipid metabolism. Nature 414: 799-806.

Diabetes complications

Tomlinson, D.R. (1999) Mitogen-activated protein kinases as glucose transducers for diabetic complications. Diabetologia 42: 1271-1281. *Brownlee, M. (2001) Biochemistry and molecular cell biology of diabetic complications. Nature 414: 813-820. Singh, R., Barden, A., Mori, T. & Beilin, L. (2001) Advanced glycation end-products: a review. Diabetologia 44: 129-146.

Gutterman, D.D. (2002) Vascular dysfunction in hyperglycemia: is protein kinase C the culprit? Circ Res 90: 5-7.

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