Articles marked * all come from a Nature Insight section on Diabetes in which there are also other good reviews: Nature 2001; 414: 781-827.
General diabetes, insulin resistance
Reaven, G.M. (1988) Role of insulin resistance in human disease. Diabetes 37: 1595-1607. This is a 'classic' article in which Gerald Reaven set out the now well-accepted idea that insulin resistance was an underlying feature of several conditions associated with increased risk of developing Type 2 diabetes and coronary heart disease. *Zimmet, P., Alberti, K.G. & Shaw, J. (2001) Global and societal implications of the diabetes epidemic. Nature 414: 782-787.
Genetics of diabetes
McCarthy, M. & Menzel, S. (2001) The genetics of type 2 diabetes. Br J Clin
Pharmacol 51: 195-199. Redondo, M.J. & Eisenbarth, G.S. (2002) Genetic control of autoimmunity in Type 1 diabetes and associated disorders. Diabetologia 45: 605-622.
Metabolism and insulin secretion in diabetes mellitus and its treatment
*Bell, G.I. & Polonsky, K.S. (2001) Diabetes mellitus and genetically programmed defects in P-cell function. Nature 414: 788-791. Langin, D. (2001) Diabetes, insulin secretion, and the pancreatic beta-cell mitochondrion. N Engl J Med 345: 1772-1774. *Moller, D.E. (2001) New drug targets for type 2 diabetes and the metabolic syndrome. Nature 414: 821-827. *Saltiel, A.R. & Kahn, C.R. (2001) Insulin signalling and the regulation of glucose and lipid metabolism. Nature 414: 799-806.
Tomlinson, D.R. (1999) Mitogen-activated protein kinases as glucose transducers for diabetic complications. Diabetologia 42: 1271-1281. *Brownlee, M. (2001) Biochemistry and molecular cell biology of diabetic complications. Nature 414: 813-820. Singh, R., Barden, A., Mori, T. & Beilin, L. (2001) Advanced glycation end-products: a review. Diabetologia 44: 129-146.
Gutterman, D.D. (2002) Vascular dysfunction in hyperglycemia: is protein kinase C the culprit? Circ Res 90: 5-7.
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All you need is a proper diet of fresh fruits and vegetables and get plenty of exercise and you'll be fine. Ever heard those words from your doctor? If that's all heshe recommends then you're missing out an important ingredient for health that he's not telling you. Fact is that you can adhere to the strictest diet, watch everything you eat and get the exercise of amarathon runner and still come down with diabetic complications. Diet, exercise and standard drug treatments simply aren't enough to help keep your diabetes under control.