As discussed in this chapter, the results of epidemiological intervention studies and short-term clinical studies on sugars and alternative sweeteners are insufficient to identify the role of these sweeteners as independent factors in the etiology of obesity. Associations found in food availability data and epidemiological studies between consumption of sweeteners and obesity perhaps indicate an overall lifestyle with a food supply that simply provides too much of a good thing (Jenkins et al., 2004). A combination of increased energy intake from all sources and decreased physical activity is the most likely explanation for the current increase in obesity.

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