Carnitine is a trimethylamine molecule that plays an important role in the transport of long-chain fatty acids into mitochondria for oxidation. There is some evidence for a beneficial effect of carnitine supplementation in training, competition and recovery from strenuous exercise and in regenerative athletics (reviewed in reference 219). The rationale for carnitine supplementation as a weight-loss agent is based on the assumption that regular oral ingestion of the substance increases its intracellular concentration, thus favoring fat oxidation. However, studies have shown that oral carnitine ingestion does not change muscle carnitine concentration in healthy non-obese humans, and that carnitine supplementation does not promote weight loss in moderately overweight humans.220'221

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